Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370997 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The synthesis of a new compound 9 containing the 4-hydroxy-2,5-cyclohexadien-1-one system, a key elements toward elucidation of the protoapigenone 1 antitumor pharmacophore, was described. The compound showed potent in vitro antitumor potency with low micromolar IC50’s against breast, ovarian, prostate, liver, pancreas, and blood cancer cell lines tested and could inhibit tumor growth in vivo but no significant impairment of hematopoiesis or immune function was observed. The minimum structural pharmacophore of 1 has now been refined.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qianying Yuan, Ziwei Liu, Chaomei Xiong, Liqian Wu, Jianping Wang, Jinlan Ruan,