| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371002 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
SAR exploration at C-6 and C-8 positions of the tricyclic sulfone series was carried out. Several functional groups were found to be well tolerated at C-6 and C-8 positions. Selective combination of C-6 and C-8 modification resulted in new tricyclic sulfone analogs with efficacy in in vivo mouse Aβ40 lowering model.
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Related Topics
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Organic Chemistry
Authors
Jing Su, Haiqun Tang, Brian A. McKittrick, Ruo Xu, John W. Clader, William J. Greenlee, Lynn Hyde, Lili Zhang,