Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371010 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Rosmarinic acid, its analogues, and a phenolic compound were obtained from G. hederacea var. longituba. There were two new compounds, methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (1) and benzyl-4′-hydroxy-benzoyl-3′-O-β-d-glucopyranoside (4), and four known compounds (2, 3, 5 and 6). The structures of these compounds were determined on the basis of spectroscopic methods. Each compound was tested by NF-κB luciferase assay and three rosmarinic acid analogues inhibited NF-κB production and the induction of COX-2 and iNOS mRNA in HepG2 cells.
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Related Topics
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Authors
JinPyo Kim, SeokBean Song, IkSoo Lee, YoungHo Kim, IckDong Yoo, InJa Ryoo, KiHwan Bae,