| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371011 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38, a selective and potent B-Raf inhibitor.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bradley J. Newhouse, Joshua D. Hansen, Jonas Grina, Mike Welch, George Topalov, Nicole Littman, Michele Callejo, Matthew Martinson, Sarah Galbraith, Ellen R. Laird, Barbara J. Brandhuber, Guy Vigers, Tony Morales, Rich Woessner, Nikole Randolph,