Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371032 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI = 61 and 38), and S-benzyl-cysteine (SI = 71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lidia A. Baltina, Vladimir V. Zarubaev, Lia A. Baltina, Iana A. Orshanskaya, Alina I. Fairushina, Oleg I. Kiselev, Marat S. Yunusov,