| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371034 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
A library of potent inhibitors of polyphenol oxidase and their structure activity relationships are described. Azachalcone derivatives were synthesized and tested for their tyrosinase inhibitory activity. Their inhibitory activities on mushroom tyrosinase using l-DOPA as a substrate were investigated. Two compounds that are the reduction congeners of the pyridinyl azachalcones strongly inhibited the enzyme activity and were more potent than the positive control kojic acid.
Graphical abstractX = N, Y = CH; IC50: 1.75 μM.X = CH, Y = N; IC50: 2.25 μM.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sini Karanayil Radhakrishnan, Ronald Gibrial Shimmon, Costa Conn, Anthony T. Baker,