| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371044 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
The worldwide threat from tuberculosis (TB) has resulted in great demand for new drugs, particularly those that can treat multidrug-resistant TB. We synthesized novel pleuromutilin derivatives with N-benzylamine side chain substituted at the C14 position and evaluated their activity in vitro against a virulent strain of Mycobacterium tuberculosis (H37Rv). The primary assay results showed that five compounds inhibited the H37Rv at 20 μM, with a MIC of one of the analogues as low as 7.2 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ying-Jie Dong, Zi-Hui Meng, Yan-Qing Mi, Chun Zhang, Zhi-Hao Cui, Peng Wang, Zhi-Bin Xu,