Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371060 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as γ-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of γ-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting Aβ42 production.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Jun Qin, Pawan Dhondi, Xianhai Huang, Mihirbaran Mandal, Zhiqiang Zhao, Dmitri Pissarnitski, Wei Zhou, Robert Aslanian, Zhaoning Zhu, William Greenlee, John Clader, Lili Zhang, Mary Cohen-Williams, Nicholas Jones, Lynn Hyde, Anandan Palani,