| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371065 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chang-Lun Shao, Chang-Yun Wang, Mei-Yan Wei, Yu-Cheng Gu, Zhi-Gang She, Pei-Yuan Qian, Yong-Cheng Lin,