| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371080 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The influence of acyclic RNA derivatives, UNA (unlocked nucleic acid) monomers, on i-DNA thermodynamic stability has been investigated. The 22 nt human telomeric fragment was chosen as the model sequence for stability studies. UNA monomers modulate i-motif stability in a position-depending manner. The largest destabilization is observed for position C14, while UNA placed in position A12 causes significant increase of i-DNA thermodynamic stability. CD curves of UNA-modified variants imply no structural changes relative to the native i-motif.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anna Pasternak, Jesper Wengel,