| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371085 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Synthesis, SAR and evaluation of styrenyl quinazolinones as novel gamma secretase modulators are presented in this communication. Starting from literature and in-house leads we evaluated a range of quinazolinones which showed good modulation of γ-secretase activity.
Graphical abstractSynthesis, SAR and evaluation of styrenyl quinazolinones as novel gamma secretase modulators are presented in this communication. Starting from literature and in-house leads we evaluated a range of quinazolinones which showed good modulation of γ-secretase activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christian Fischer, Sanjiv Shah, Bethany L. Hughes, George N. Nikov, Jamie L. Crispino, Richard E. Middleton, Alexander A. Szewczak, Benito Munoz, Mark S. Shearman,