| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371093 | Bioorganic & Medicinal Chemistry Letters | 2011 | 7 Pages |
Abstract
Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.
Graphical abstractThe evolution of an advanced lead compound 19 through a scaffold hopping approach guided by structure-based drug design is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Craig Jamieson, John K.F. Maclean, Christopher I. Brown, Robert A. Campbell, Kevin J. Gillen, Jonathan Gillespie, Bert Kazemier, Michael Kiczun, Yvonne Lamont, Amanda J. Lyons, Elizabeth M. Moir, John A. Morrow, John Pantling, Zoran Rankovic, Lynn Smith,