Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371098 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with Ki values of 0.46 and 0.59 μM, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydrazone groups.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Frank Sielaff, Manuel E. Than, Dorian Bevec, Iris Lindberg, Torsten Steinmetzer,