| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371099 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A new class of 7-azaindole analogs of MK-7246 as potent and selective CRTH2 antagonists is reported. The SAR leading to the identification of the optimal azaindole regioisomer as well as the pharmacokinetics and off-target activities of the most potent antagonists are disclosed.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniel Simard, Yves Leblanc, Carl Berthelette, M. Helmi Zaghdane, Carmela Molinaro, Zhaoyin Wang, Michel Gallant, Stephen Lau, Trinh Thao, Martine Hamel, Rino Stocco, Nicole Sawyer, Susan Sillaots, Francois Gervais, Robert Houle, Jean-François Lévesque,