| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371107 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs.
Graphical abstractA compound extracted from Forsythia suspensa specifically promoted shp2 activity in a dose-dependent manner and was identified as oleanolic acid (OA).Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yanyan Bu, Tao Shi, Minghui Meng, Guiping Kong, Yingpu Tian, Quancheng Chen, Xinsheng Yao, Gensheng Feng, Haifeng Cheng, Zhongxian Lu,