Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371118 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
A series of isatin analogs containing a hydrophilic group, including a pyridine ring, ethylene glycol group, and a triazole ring, have been synthesized, and their inhibition potency for caspase-3 was measured both in vitro (i.e., recombinant enzyme) and in whole cells (HeLa cells). The analogs having a hydrophilic group, including 12, 13, 16, 38, and 40, have dramatically increased activity in vitro and in HeLa cells compared to the corresponding unsubstituted N-phenyl isatin analogs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wenhua Chu, Justin Rothfuss, Dong Zhou, Robert H. Mach,