| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371119 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC50 and EC50 values, with cytotoxicity CC50 indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Feng Ni, Smitha Kota, Virginia Takahashi, A. Donny Strosberg, John K. Snyder,