Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371120 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 months old) mice hippocampus sections incubated with these derivatives revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compounds on Aβ40 fibril formation. This study highlights the potential of proflavine as a molecular scaffold for designing new Aβ imaging agents, its native fluorescence allowing in vitro neuropathological staining in AD damaged brain sections.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dominique Garin, Fatima Oukhatar, Andrew B. Mahon, Andrew C. Try, Michel Dubois-Dauphin, Frank M. Laferla, Martine Demeunynck, Marcelle Moulin Sallanon, Sabine Chierici,