| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371125 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A new series of IGF-1R inhibitors related to hydantoins were identified from a lead originating from HTS. Their noncompetitive property as well as their slow binding characteristics provided a series of compounds with unique selectivity and excellent cellular activities.
Graphical abstractA new series of IGF-1R inhibitors related to hydantoins were identified from a lead originating from HTS. Their noncompetitive property as well as their slow binding characteristics provided a series of compounds with unique selectivity and excellent cellular activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dominique Lesuisse, Jacques Mauger, Conception Nemecek, Sébastien Maignan, Janine Boiziau, Greg Harlow, Augustin Hittinger, Swen Ruf, Hartmut Strobel, Anil Nair, Kurt Ritter, Jean-Luc Malleron, Anne Dagallier, Youssef El-Ahmad, Jean-Pierre Guilloteau,