| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371127 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
16-Dehydropregnenolone undergoes a smooth annulation with propan-1-amine and aromatic aldehydes. Several amine derivatives of 16- dehydropregnenolone were synthesized and evaluated as inhibitors of DPP-IV. The structures of compounds were confirmed by 1H, 13C, NMR and mass spectral analysis. Among 17 compounds evaluated only five compounds 1, 9, 13, 15 and 16 demonstrated significant inhibition of DPP. This study suggest that introduction of appropriate substituents in the 16-dehydropregnenolone plays an important role in DPP-IV inhibitory activity.
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Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Manmeet Kumar, Preeti Rawat, Mohammad Faheem Khan, Arun Kumar Rawat, Arvind Kumar Srivastava, Rakesh Maurya,