| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371129 | Bioorganic & Medicinal Chemistry Letters | 2011 | 8 Pages |
Abstract
A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11β-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11β-HSD1 with an appropriate ADME profile and ex vivo activity in target tissues.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Olivier Venier, Cécile Pascal, Alain Braun, Claudie Namane, Patrick Mougenot, Olivier Crespin, François Pacquet, Cécile Mougenot, Catherine Monseau, Bénédicte Onofri, Rommel Dadji-Faïhun, Céline Leger, Majdi Ben-Hassine, Thao Van-Pham, Jean-Luc Ragot,