| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371132 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A number of mono- or diaminoalkylated indeno[1,2-c]isoquinolin-5,11-diones analogs of 1 were synthesized and evaluated for their DNA binding affinities, topoisomerase inhibition properties and antiproliferative activities against human cancer cell lines (HL60). Impact of the side chain connected to the aromatic D ring and to the N6 lactam position on the biological profile will be discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones](/preview/png/1371132.png "First Page Preview: Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones")
Authors
Gang Ahn, Nadège Schifano-Faux, Jean-François Goossens, Brigitte Baldeyrou, Axel Couture, Pierre Grandclaudon, Amélie Lansiaux, Adina Ryckebusch,