Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371137 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
The 80% methanolic extract of Euonymus alatus leaves and twigs afforded three new lignans, (−)-threo-4,9,4′,9′-tetrahydroxy-3,7,3′,5′-tetramethoxy-8-O-8′-neolignan (1), (−)-threo-4,9,4′,9′-tetrahydroxy-3,5,7,3′-tetramethoxy-8-O-8′-neolignan (2), (7R,8R,7′R)-(+)-lyoniresinol (3), together with seventeen known lignans (4–20). The structures of 1–20 were elucidated by extensive 1D and 2D spectroscopic methods including 1H NMR, 13C NMR, 1H–1H COSY, HMQC, HMBC and NOESY. All the isolated compounds except for dilignans (19 and 20) significantly inhibited nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells.
Graphical abstractThe 80% methanolic extract of Euonymus alatus leaves and twigs afforded three new lignans, (−)-threo-4,9,4′,9′-tetrahydroxy-3,7,3′,5′-tetramethoxy-8-O-8′-neolignan (1), (−)-threo-4,9,4′,9′-tetrahydroxy-3,5,7,3′-tetramethoxy-8-O-8′-neolignan (2), (7R,8R,7′R)-(+)-lyoniresinol (3), together with seventeen known lignans (4–20). The structures of 1–20 were elucidated by extensive 1D and 2D spectroscopic methods including 1H NMR, 13C NMR, 1H–1H COSY, HMQC, HMBC and NOESY. All the isolated compounds except for dilignans (19, 20) significantly inhibited nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells.Figure optionsDownload full-size imageDownload as PowerPoint slide