| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371148 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.
Graphical abstractWe report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Qingmei Hong, Raman K. Bakshi, Brenda L. Palucki, Min K. Park, Zhixiong Ye, Shuwen He, Patrick G. Pollard, Iyassu K. Sebhat, Jian Liu, Liangqin Guo, Doreen E. Cashen, William J. Martin, David H. Weinberg, Tanya MacNeil, Rui Tang,