Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371151 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
A series of phenoxyacetic acids as subtype selective and potent hPPARδ partial agonists is described. Many analogues were readily accessible via a single solution-phase synthetic route which resulted in the rapid identification of key structure–activity relationships (SAR), and the discovery of two potent exemplars which were further evaluated in vivo. Details of the SAR, optimization, and in vivo efficacy of this series are presented herein.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Karen A. Evans, Barry G. Shearer, David D. Wisnoski, Dongchuan Shi, Steven M. Sparks, Daniel D. Sternbach, Deborah A. Winegar, Andrew N. Billin, Christy Britt, James M. Way, Andrea H. Epperly, Lisa M. Leesnitzer, Raymond V. Merrihew, Robert X. Xu,