| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371153 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A new series of imidazopyridine CB2 agonists is described. Structural optimization improved CB2/CB1 selectivity in this series and conferred physical properties that facilitated high in vivo exposure, both centrally and peripherally. Administration of a highly selective CB2 agonist in a rat model of analgesia was ineffective despite substantial CNS exposure, while administration of a moderately selective CB2/CB1 agonist exhibited significant analgesic effects.
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Related Topics
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Organic Chemistry
Authors
B. Wesley Trotter, Kausik K. Nanda, Christopher S. Burgey, Craig M. Potteiger, James Z. Deng, Ahren I. Green, John C. Hartnett, Nathan R. Kett, Zhicai Wu, Darrell A. Henze, Kimberly Della Penna, Reshma Desai, Michael D. Leitl, Wei Lemaire,