Article ID Journal Published Year Pages File Type
1371164 Bioorganic & Medicinal Chemistry Letters 2011 4 Pages PDF
Abstract

The total asymmetric synthesis of (+)- and (−)-clusianone and (+)- and (−)-clusianone methyl enol ether is reported. Asymmetric induction is achieved through the use of ACC alkylation, providing the key intermediates with an er of 99:1. The four synthetic compounds were evaluated for their anti-HIV activity. Both (+)- and (−)-clusianone displayed significant anti-HIV activity.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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