Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371164 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The total asymmetric synthesis of (+)- and (−)-clusianone and (+)- and (−)-clusianone methyl enol ether is reported. Asymmetric induction is achieved through the use of ACC alkylation, providing the key intermediates with an er of 99:1. The four synthetic compounds were evaluated for their anti-HIV activity. Both (+)- and (−)-clusianone displayed significant anti-HIV activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michelle R. Garnsey, James A. Matous, Jesse J. Kwiek, Don M. Coltart,