| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371171 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We constructed a library of sugar-dipeptide conjugate to find out the best complementary against hydrophobic pocket of α-glucosidase. The best substrate showed 150-fold improved Km value relative p-acetaminophenyl-α-d-glucopyranoside for α-glucosidase from Bacillus stearothermophillus. Using information from the complementary, we synthesized sp-WY and β-Glc-sp-WY, which selectivity inhibited the cognate enzyme.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sangeun Park, Soonsil Hyun, Jaehoon Yu,