| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371182 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and synthesized. These efforts identified a series of novel, noncovalent FAAH inhibitors with in vitro potency comparable to known covalent FAAH inhibitors. The mechanism of action for these compounds was determined through a combination of SAR and co-crystallography with rat FAAH.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Darin J. Gustin, Zhihua Ma, Xiaoshan Min, Yihong Li, Christine Hedberg, Cris Guimaraes, Amy C. Porter, Michelle Lindstrom, Dianna Lester-Zeiner, Guifen Xu, Timothy J. Carlson, Shouhua Xiao, Cesar Meleza, Richard Connors, Zhulun Wang, Frank Kayser,