Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371186 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Our goal in the search for potentially bioactive analogues of KRN 7000 was to design an easy synthetic approach to a library of analogues using a strategy recently developed in our laboratory based on a Nucleophilic addition followed by an Epoxide Opening (the NEO strategy). Through the use of a common pivotal structure, a new C-galactoside ester analogue (23) was synthesized which showed an encouraging TH2 biased response during preliminary biological tests.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aline Banchet-Cadeddu, Agathe Martinez, Stéphane Guillarme, Véronique Parietti, Fanny Monneaux, Eric Hénon, Jean-Hugues Renault, Jean-Marc Nuzillard, Arnaud Haudrechy,