Article ID Journal Published Year Pages File Type
1371186 Bioorganic & Medicinal Chemistry Letters 2011 5 Pages PDF
Abstract

Our goal in the search for potentially bioactive analogues of KRN 7000 was to design an easy synthetic approach to a library of analogues using a strategy recently developed in our laboratory based on a Nucleophilic addition followed by an Epoxide Opening (the NEO strategy). Through the use of a common pivotal structure, a new C-galactoside ester analogue (23) was synthesized which showed an encouraging TH2 biased response during preliminary biological tests.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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