| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371191 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Synthesis of 1α,25-dihydroxyvitamin D3-3β-bromoacetate (1,25(OH)2D3-3-BE), a potential anti-cancer agent is presented. We also report that mechanism of action of 1,25(OH)2D3-3-BE may involve reduction of its catabolism, as evidenced by the reduced and delayed expression of 1α,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) gene in cellular assays.
Graphical abstractSynthesis of 1α,25-dihydroxyvitamin D3-3β-bromoacetate, a potential anti-cancer agent, and its probable mechanism of action, denoting its reduced catabolism is presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Rahul Ray, James R. Lambert,