| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371196 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Optimization of a water soluble, moderately potent lead series of isoxazole-3-carboxamides was conducted, affording a compound with the requisite balance of potency, solubility and physicochemical properties for in vivo use. Compound 8e was demonstrated to be efficacious in a rat model of inflammatory pain, following oral administration.
Graphical abstractOptimization of a water soluble, moderately potent lead series of isoxazole-3-carboxamides was conducted, affording a compound with the requisite balance of potency, solubility and physicochemical properties for in vivo use. Compound 8e was demonstrated to be efficacious in a rat model of inflammatory pain, following oral administration.Figure optionsDownload full-size imageDownload as PowerPoint slide
