Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371246 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes, we developed a compound library based on this heterocyclic scaffold. We found that several library members displayed low micromolar antiproliferative activity and induced apoptosis in human cancer cells. Selected compounds showed promising activity against cancer cell lines resistant to proapoptotic stimuli, demonstrating their potential in treating cancers with dismal prognoses.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Igor V. Magedov, Artem S. Kireev, Aaron R. Jenkins, Nikolai M. Evdokimov, Dustin T. Lima, Paul Tongwa, Jeff Altig, Wim F. A. Steelant, Severine Van slambrouck, Mikhail Yu. Antipin, Alexander Kornienko,