| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371261 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A detailed structure–activity relationship study of a novel series of pyridazine-based small molecule glucan synthase inhibitors is described. The optimization of the PK profile of this series led to the discovery of compound 11g, which demonstrated in vivo potency ip in a lethal fungal infection model.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rongze Kuang, Heping Wu, Pauline C. Ting, Robert G. Aslanian, Jianhua Cao, David W. Kim, Joe F. Lee, John Schwerdt, Gang Zhou, R. Jason Herr, Andrew J. Zych, Jinhai Yang, Sang Q. Lam, David M. Jenkins, Samuel A. Sakwa, Samuel Wainhaus, Todd A. Black,