| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371264 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The chemoenzymatic deacylation of ramoplanin A2 is described for the first time: ramoplanin A2 was Boc-protected and hydrogenated to Boc-protected tetrahydroramoplanin, which was subsequently deacylated using an acylase from Actinoplanes utahensis NRRL 12052. The chemoenzymatic process proceeded with 80% overall yield, which favourably compares with the previously described chemical deacylation.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raffaella Gandolfi, Flavia Marinelli, Enzio Ragg, Diego Romano, Francesco Molinari,