Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371266 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of 2-oxaisocephems with a thio-substituted methyl group at the 3-position and a [2-(5-amino-1,2,4-thiadizol-3-yl)-2-(Z)-alkoxyimino]acetamido moiety at 7-position were synthesized and tested for their antibacterial activities. The analogs 17c and 17f have well-balanced potency and significantly enhanced activity as compared with the reference compound ceftazidime.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jianbo Wu, Xueying Wu, Fan Lei, Huajie Yuan, Li Hai, Yong Wu,