| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371284 | Bioorganic & Medicinal Chemistry Letters | 2015 | 8 Pages |
Abstract
The bacterium responsible for tuberculosis is increasing its resistance to antibiotics resulting in new multidrug-resistant Mycobacterium tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). In this study, several analytical techniques including NMR, FT-ICR, MALDI-MS, LC–MS and UV/Vis are used to study the copper–Rifampicin–Polyethylene glycol (PEG-3350) complex. The copper (II) cation is a carrier for the antibiotic Rifampicin as well as nutrients for the bacterium. The NIH-NIAID cell line containing several Tb strains (including antibiotic resistant strains) is tested against seven copper–PEG–RIF complex variations.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thomas Manning, Rachel Mikula, Greg Wylie, Dennis Phillips, Jackie Jarvis, Fengli Zhang,