Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371319 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
A novel linear polyketide, amphirionin-2 (1), with two unique hexahydrofuro[3,2-b]furan moieties has been isolated from the cultivated algal cells of a benthic dinoflagellate Amphidinium sp. (strain KCA09051). The structure was elucidated on the basis of detailed analyses of 2D NMR data, and the absolute configuration of C-5 was determined by using modified Mosher’s method. Amphirionin-2 (1) exhibited potent cytotoxic activity against human colon carcinoma Caco-2 cells and human lung adenocarcinoma A549 cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Keiko Kumagai, Mika Minamida, Mai Akakabe, Masayuki Tsuda, Yuko Konishi, Akira Tominaga, Masashi Tsuda, Eri Fukushi, Jun Kawabata,