| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371334 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
Integration of viral DNA into the host cell genome is an obligatory process for successful replication of HIV-1. Integrase catalyzes the insertion of viral DNA into the target DNA and is a validated target for drug discovery. Herein, we report the synthesis, antiviral activity and pharmacokinetic profiles of several C2-carbon-linked heterocyclic pyrimidinone-4-carboxamides that inhibit the strand transfer step of the integration process.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
B. Narasimhulu Naidu, Margaret E. Sorenson, Manoj Patel, Yasutsugu Ueda, Jacques Banville, Francis Beaulieu, Sagarika Bollini, Ira B. Dicker, Helen Higley, Zeyu Lin, Lori Pajor, Dawn D. Parker, Brian J. Terry, Ming Zheng, Alain Martel,