Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371348 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
The significance of this study was to prepare various isoniazid derivatives by introducing the isoniazid core into several molecules to explore the possibilities of some altered biological activities. Series of 6-substituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole (3a–g) and 1,3,4-oxadiazole (4a–g and 5) derivatives of isoniazid were synthesized in satisfactory yield and pharmacologically evaluated for their anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities by known experimental models.
Graphical abstractFacile and efficient synthesis of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide