| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371351 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
We found that the most promising compound 4a (R-132811) in this series inhibits the production of the proinflammatory cytokines in vitro and in vivo (e.g., TNFα IC50 = 0.026 μM, TNFα ID50 = 0.93 mg/kg).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akira Nakao, Nobuyuki Ohkawa, Takayoshi Nagasaki, Takashi Kagari, Hiromi Doi, Takaichi Shimozato, Shigeru Ushiyama, Kazumasa Aoki,