| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371357 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The discovery of novel pyrazoline derivatives as B-Raf (V600E) inhibitors is described in this report. Chemical modification of the pyrazoline scaffold led to the development of SAR and identified potent and selective inhibitors of B-Raf (V600E). Determination of the pharmacokinetic properties of selected inhibitors is also reported.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Matthew O. Duffey, Ruth Adams, Christopher Blackburn, Ryan W. Chau, Susan Chen, Katherine M. Galvin, Khristofer Garcia, Alexandra E. Gould, Paul D. Greenspan, Sean Harrison, Shih-Chung Huang, Mi-Sook Kim, Bheemashankar Kulkarni, Steven Langston,