| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371360 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The syntheses and structure–activity relationships of the tartrate-based TACE inhibitors are discussed. The optimization of both the prime and non-prime sites led to compounds with picomolar activity. Several analogs demonstrated good rat pharmacokinetics.
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Related Topics
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Organic Chemistry
Authors
Dansu Li, Janeta Popovici-Muller, David B. Belanger, John Caldwell, Chaoyang Dai, Maria David, Vinay M. Girijavallabhan, Brian J. Lavey, Joe F. Lee, Zhidan Liu, Rob Mazzola, Razia Rizvi, Kristin E. Rosner, Bandarpalle Shankar, Jim Spitler,