| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371386 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A remarkably concise, chromatography-free route to the parent compound of the paullone family of cyclin-dependent kinase (CDK) inhibitors is reported. A similar strategy allowed the synthesis of the hitherto missing 9-azapaullone and its protonated, N-oxidised and N-alkylated derivatives. Screening studies identified an active and strongly selective inhibitor of CDK9/cyclin T.
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Related Topics
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Organic Chemistry
Authors
David P. Power, Olivier Lozach, Laurent Meijer, David H. Grayson, Stephen J. Connon,