Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line

The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERβ binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.

Graphical abstractThree dimensional structure of ER β docked with compound 5a using Maestro.Beta sheet has been shown in blue color and compound has been shown as ball and stick model.Figure optionsDownload full-size imageDownload as PowerPoint slide