Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371405 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
In this work, we tried to find a new scaffold for a PDE3 using virtual screening for the obesity treatment. We first analyzed structural features for the known PDE3 inhibitors based on the PDE3B-ligand complex structure, and then carried out a docking study based on PDE3B 3D structure. We obtained a compound as potent PDE3 inhibitor stimulating lipolysis in murine adipocytes and human adipocytes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ki Young Kim, Hyuk Lee, Sung-Eun Yoo, Seong Hwan Kim, Nam Sook Kang,