| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371423 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of tetrahydroquinoline derivatives were synthesized and profiled for their ability to act as glucocorticoid receptor selective modulators. Structure–activity relationships of the tetrahydroquinoline B-ring lead to the discovery of orally available GR-selective agonists with high in vivo activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew R. Hudson, Robert I. Higuchi, Steven L. Roach, Mark E. Adams, Angela Vassar, Peter M. Syka, Dale E. Mais, Jeffrey N. Miner, Keith B. Marschke, Lin Zhi,