| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371426 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M1 positive allosteric modulators was examined. While the SAR was generally flat, compounds were identified with high CNS exposure to warrant additional in vivo evaluation.
Graphical abstractSAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M1 positive allosteric modulators was examined.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott D. Kuduk, Ronald K. Chang, Christina N. Di Marco, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, Charles D. Thompson, George D. Hartman, Mark T. Bilodeau,