| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371437 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Synthesis, and structure–activity relationship (SAR) studies of the novel IKK-β inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.
Graphical abstractIKK-β inhibitors characterized by a dihydrothieno [2,3-e] indazole core are reported. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Hiroyasu Takahashi, Mariko Shinoyama, Takashi Komine, Muneki Nagao, Masashi Suzuki, Hisatoshi Tsuchida, Koichi Katsuyama,