Design, synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes

Five dinuclear platinum(II) complexes with a novel chiral ligand, 2-(((1R,2R)-2-aminocyclohexylamino)methyl)phenol (HL), were designed, prepared and spectrally characterized. In vitro cytotoxicity of all the resulting platinum(II) compounds was evaluated against human HEPG-2, A549 and HCT-116 cell lines, respectively. Results indicated that all compounds showed positive biological activity. Particularly, compound D4 has lower IC50 values than carboplatin toward HEPG-2 and A549, while compound D5 shows better activity than carboplatin against A549.

Graphical abstractNovel dinuclear platinum(II) complexes were designed, prepared and biologically evaluated. Results indicated that compound D4 showed better antitumor activity than carboplatin against two selected human cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide